The present experiments were carried out in tow consecutive year of Kharif and Rabi season of 2003-04 and 2004-05 at Agriculture Research Farm of Shri Durga Ji Post Graduate College Chandeshwar Azamgarh under afflicted Veer Bahadur Singh Purvanchal University, Jaunpur (UP) with a view to find out the production potential of maize-wheat cropping system under different fertilizer doses with soil conditions. The results revealed that the wheat grain equivalent yield was maximum of 79.86 q/ha with FYM application while gypsum reduced 75.29 q/ha minimum equivalent yield of 72.50 q/ha was recorded in control treatment. The gross income or Rs. 63159 and Rs. 63878 /ha and net profit of Rs. 28246 and Rs. 29017/ha were significantly more obtained with FYM from maize-wheat system during both year, respectively while, gypsum gave gross income of Rs. 59199 and 60653/ha and net profit Rs. 26479 and Rs. 27933/ha during respective years. In case of fertilizer, significantly maximum equivalent yield of 80.85 and 82.07 q/ha was obtained at 125% fertilizer during first and second year, respectively. The highest gross income of Rs. 63798 and Rs. 64854/ha was achieved with 125% fertilizer while maximum net profit of Rs. 28901 and Rs. 29682/ha was obtained with 100% RDF during first and second year. Therefore, application of FYM @ 5 ton/ha along with 100% RDF proved to be most economic combination of the system as it gave 84.74 and 85.97 q/ha wheat grain equivalent yield and earned maximum net profit of Rs. 30676 and Rs. 31026/ha during both years, respectively.